Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a combined operation on an hidden munitions depot in Syria used by the Daesh militant organization, per a report from the UK's MoD.
The location, located using intelligence, was believed to be housing weapons and explosive materials, the statement said, and was located in hills just above Palmyra in Syria's central region.
"Our aircraft utilized Paveway IV guided bombs to hit a several entry passages down to the facility... initial indications indicate the strike was effective," officials stated.
There was no sign of any civilian impact in the attack conducted Saturday night and all the aircraft returned safely, the ministry further stated.
The Typhoon fighters were assisted by a Voyager tanker plane.
Daesh - alternatively referred to as the so-called Islamic State - enforced militant control over significant areas in Iraq and Syria before its territorial defeat in 2019.
"This action underscores our UK leadership, and determination to stand shoulder to shoulder with allied nations, to eliminate any resurgence of IS and their dangerous and violent ideologies in the region," UK Defence Secretary the Defence Secretary stated.
RAF aircraft have performed surveillance missions over Syria to "deter any efforts to regroup" of Islamic State subsequent to its defeat at the battle of Baghuz in 2019, the MoD reported.
"I want to thank all the members of the UK armed forces who took part in this strike for their professionalism and their valour," he said. "They were part of thousands of British personnel on duty over Christmas and New Year. This mission, to eliminate militants who endanger our way of life, shows how UK forces are prepared to act, continuously, keeping Britain secure at home and influential overseas."
Last December, the American forces carried out what it termed a "major assault" targeting Islamic State objectives in Syria, subsequent to an attack killed two American soldiers and a local interpreter in the Palmyra area.
The UN says Islamic State still maintains an estimated 5,000 to 7,000 fighters in Iraq and Syria.